ABSTRACT
Data concerning the relationship between hepatitis B virus (HBV) genotypes and liver histology are scarce. The aim of this study was to compare HBV non-B and non-C genotypes according to demographic features, clinical status, HBV-DNA levels and liver histology in Rio de Janeiro. One hundred twenty one consecutive chronic HBV-infected patients were enrolled during two-year period and data were prospectively collected. Sera were tested for HBV genotyping using restriction fragment length polymorphism. Liver biopsy was obtained from patients with either increased alanine aminotransferase (ALT) or HBV-DNA levels. Genotype A was the most common, found in 82 (68%) patients, followed by F in 19 (15%), D in 17 (14%), B in one (1%) and C in two (2%). There was no association between HBV genotypes A, D and F and gender (p = 0.37), age (p = 0.78), race (p = 0.22), mode of infection (p = 0.94), HB "e" antigen status (p = 0.37) and HBV-DNA levels (p = 0.47). The ALT levels were lower in genotype D (75%) compared with A (47%) and F (55%) (p = 0.05). Liver biopsy showed lower inflammation [histological activity index (HAI) = 4] and fibrosis (F) (= 0) scores in genotype D than in genotypes A (HAI = 5, p < 0.001; F = 2, p = 0.008) or F (HAI = 5, p = 0.009; F = 2, p = 0.01). Genotype A was the most prevalent in chronic HBV-infected patients and genotype D patients presented with less intense liver disease.
Subject(s)
Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Young Adult , DNA, Viral/genetics , Hepatitis B virus/genetics , Hepatitis B, Chronic/virology , Liver Cirrhosis/virology , Alanine Transaminase/analysis , Brazil , Cross-Sectional Studies , Fibrosis , Genotype , Hepatitis B, Chronic/pathology , Liver Cirrhosis/pathology , Polymerase Chain Reaction , Severity of Illness IndexABSTRACT
É um estudo aprofundado das hepatites virais, em sua epidemiologia, clínica e no diagnóstico e tratamento das formas agudas e crônicas. As hepatites virais B e C são abordadas também em situações especiais, como no paciente renal crônico, no pós-transplante, nas co-infecções HIV-VHC, HIV-VHB e nas hepatites agudas com evolução para formas fulminantes. Questões relevantes e atuais sobre a esteatoepatite não-alcoólica, hepatites medicamentosas, hepatites alcoólica e auto-imune, que podem ter evolução para formas graves, com desenvolvimento de cirrose hepática, são relevantes nesta obra. Em capítulo especial é analisado o carcinoma hepatocelular, visto sua elevada frequência e relação com as hepatites virais (VHB e VHC).